Oxigene inc,wie Kerxy vor 2 jahren:Einstiegskurse!

hatte zum 31.03. noch 14 Millionen USD an Cash, wobei sich allerdings die Anzahl der Outstanding Shares bis zum 15.04. fast verdoppelt hat...

http://secfilings.nasdaq.com/...=10-Q&RcvdDate=4/29/2010&pdf=

Schaut Euch mal AVII an. Die haben am Freitag einen Kontrakt mit einer Behörde des U.S.-Verteigigungsministeriums geschlossen, der ihnen 291 Millionen USD bringt. Derzeit wird die Gesellschaft mit gerademal knapp 200 Millionen USD bewertet.

Denke hier lauert noch erhebliches Potential...  

Bitte lese auf der Seite von SNSS die Pressemitteilung vom 30.06.2010 ganz durch und
dann sage mir Bitte wieviel Cash Sunesis zum 30.06.2010 hat.  

Ich sehe jedenfalls keine NEWS vom 30.06.2010. Zudem gibt es auch noch kein Q-10 Filing vom 30.06.2010.

Wer Du mehr weist, dann bitte verlinken!  

Also,wenn du sagst,AVII ist nur knapp 200 Mio wert,dann muss ich schon stutzen ! Und wieso sollte AVII den zuschlag für H1n1 bekommen,wieso nicht Biocryst ?? Biocryst ist doch viel weiter mit dem impfstoff,dafür aber noch teurer als AVII,also ich werd nicht schlau draus ....

MFG
Chali  

wobei es m.W. aber nicht um den Zuschlag für H1N1, sondern einen Impfstoff gegen das Ebola- und Marburg-Virus geht...

http://www.thestreet.com/_nasdaq/story/10812353/1/...EE&cm_ite=NA  

http://www.mysmartrend.com/news-briefs/news-watch/...xgn-rxii-pran-pp  

Doctorchen,das ist hier genau das richtige für dich,aber beeil dich,bevor es zu spät ist ....

MFG
Chali  

OXiGENE, Inc. (NASDAQ: OXGN) jumped up by 9.93% and closed at $0.33 whereas total traded volume stood at 2.71 million shares. OXiGENE, Inc. (OXiGENE) is a clinical-stage, biopharmaceutical company developing therapeutics to treat cancer and eye diseases.

OXiGENE Announces Clinical Data From FACT Study to be Presented at the 14th International Thyroid Congress

SOUTH SAN FRANCISCO, Calif., June 24, 2010 (GLOBE NEWSWIRE) -- OXiGENE, Inc. (Nasdaq:OXGN - News), a clinical-stage, biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases, announced today that data from its clinical trials of ZYBRESTAT and chemotherapy in patients with anaplastic thyroid cancer (ATC), will be presented at the upcoming 14th International Thyroid Congress in Paris, France, on September 12, 2010. OXiGENE will release a summary of results immediately after they are presented.

ZYBRESTAT Presentation Details:

Oral Presentation Title: RANDOMIZED PHASE 2/3 TRIAL OF A TUMOR VASCULAR DISRUPTING AGENT FOSBRETABULIN TROMETHAMINE (CA4P) WITH CARBOPLATIN (C), AND PACLITAXEL (P) IN ANAPLASTIC THYROID CANCER (ATC): INTERIM SAFETY AND EFFICACY RESULTS OF THE FACT TRIAL

Presenter: Rossella Elisei, M.D.
Session Title: Prospective trials in refractory thyroid cancers
Date: Sunday 12 Sept.
Time of session: 14:45 - 16:15
Location: Room Bordeaux - level 3
About ZYBRESTAT (fosbretabulin)

ZYBRESTAT is being evaluated in a Phase 2 study of patients with non-squamous non-small cell lung cancer and other clinical trials. OXiGENE believes that ZYBRESTAT is poised to become an important product in a novel class of small-molecule drug candidates called vascular disrupting agents. Through interaction with vascular endothelial cell cytoskeletal proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and causing death of tumor cells. In clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and selective activity against tumor vasculature, as well as clinical activity against anaplastic thyroid cancer, ovarian cancer and various other solid tumors.

About OXiGENE

OXiGENE is a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases. The Company's major focus is developing vascular disrupting agents that selectively disrupt abnormal blood vessels associated with solid tumor progression and visual impairment. OXiGENE is dedicated to leveraging its intellectual property and therapeutic development expertise to bring life-extending and life-enhancing medicines to patients.

u.a. im letzten Conference Call: "We very much look forward to September...!"

Bist du etwa dabei bei Oxigene ? Deine bisherigen Investments wie YRCW waren ja alle ziemlich mies,was !? Also ich bin komplett raus aus OXGN,weil die eigentlich sehr bald schon pleite sind,wenn da keine neue Kohle kommt ....

MFG
Chali  

dich soll einer verstehen.
Als Treadgründer hast Du doch das Papierchen immer über den grünen Klee hinaus gelobt.
Woher der Sinneswandel?
Gruß Wilbär.
PS.Allein aus diesem Grunde bin ich auch dabei.
Was hältst Du als Biospezi eigentlich von YM-Bio?
Gruß Wilbär.

Du solltest  nie die Meinung anderer adaptieren,sondern dir lieber selbst ein bild von der entsprechenden aktie machen ! Wie gesagt,die Technologie von Oxigene bleibt interessant,aber finanziell krichen die langsam aber sicher auf dem Zahnfleisch,wenn du unsicher bist,würde ich noch die Daten am 12.09 abwarten und dann vielleicht mit Gewinn raus ??!

Ja,YM ,diese canadische biotechaktie,keine Ahnung ! Ich interessiere mich ansonsten  noch für Sangamo Bioscience (SGMO),da bin ich auch drin ....

MFG
Chali  

Ich war nie bei YRCW, wie kommst du da drauf??
zuletzt war oder bin ich bei  NAVIGATOR RES LTD und SUNWIN INTL N

so ein Bauchgefühl, als wenn da jemand mehr weiss wie ich

OXGN-ZYBRESTAT(TM) (CA4P) Improves Overall Survival in a Phase 2/3 Trial (FACT Study) of Patients With Anaplastic Thyroid Cancer (ATC

09/12/2010 @ 8:45AM

Median Overall Survival of Patients Receiving ZYBRESTAT Plus Chemotherapy was 5.1 Months, Compared With 4.1 Months for Patients Receiving Chemotherapy Alone

Patients Alive at One-Year More Than Doubled With ZYBRESTAT Plus Chemotherapy Compared With Chemotherapy Alone (23% Vs. 9%)

Almost Half of Patients Treated With ZYBRESTAT Plus Chemotherapy (48%) Were Alive at Six Months, Compared With 37% Treated With Chemotherapy Alone


OXiGENE, (Nasdaq:OXGN), a clinical-stage, biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases, announced that positive results from a randomized, controlled, Phase 2/3 study of ZYBRESTAT (fosbretabulin, CA4P) were presented today at the 14th International Thyroid Congress in Paris, France by Rossella Elisei, M.D., of the University of Pisa. In this 80-patient study, the median overall survival (OS) time was 5.1 months for patients who received ZYBRESTAT and chemotherapy when compared with a median survival time of 4.1 months for patients receiving chemotherapy alone (Hazard Ratio 0.71), which represents a 29% reduction in the risk of dying for patients receiving ZYBRESTAT and chemotherapy. Of patients treated with ZYBRESTAT and chemotherapy, 48% were alive at six months, compared with 37% percent of patients treated with the control arm regimen. At one year, 23% of patients treated with ZYBRESTAT and chemotherapy were alive compared to 9% of patients treated with chemotherapy alone. The most common side effects reported with ZYBRESTAT and chemotherapy were neutropenia, transient hypertension and tumor pain.

"The results of this study show a clearly demonstrated survival benefit with only transient, manageable side effects," said Michael Tuttle, M.D., Endocrinologist at Memorial Sloan-Kettering Cancer Center who specializes in caring for patients with advanced thyroid cancer. "ZYBRESTAT plus chemotherapy has demonstrated the first significant increase in overall survival without serious side effects in patients with anaplastic thyroid cancer, which should make this an attractive therapeutic intervention for patients for whom there are no other approved effective therapies."

"These exciting data, which show improvements in all key endpoints, including 48% of patients surviving 6 months and 23% of patients surviving one year, represent a potential breakthrough in the treatment of this highly lethal disease, which has a historic one year survival rate of less than 10%," said Bryan McIver, M.B., Ch.B., Ph.D., Endocrinologist at the Mayo Clinic. "Results from this study of ZYBRESTAT are exciting and show that a vascular disrupting agent, in combination with chemotherapy, could potentially be the first effective chemotherapeutic treatment option for these patients."

ZYBRESTAT (fosbretabulin, CA4P) has received orphan drug designation for the treatment of anaplastic thyroid cancer, medullary thyroid cancer, and stage IV papillary or follicular thyroid cancer.

"We believe these promising data represent a major improvement over current standard of care for ATC patients, underscore the antitumor activity of this molecule and have positive implications for future development in other cancer indications," said Peter J. Langecker, M.D., Ph.D., OXiGENE Chief Executive Officer. "The encouraging data presented today represent an exciting milestone for OXiGENE and we are deeply grateful to our patients and investigators who participated in this important clinical study."

Continued Dr. Langecker: "We plan to present additional data from the FACT trial at the European Society for Medical Oncology or ESMO meeting in Milan in October. These data will include an additional month of follow-up plus a sub-group analysis that we anticipate will further underscore ZYBRESTAT's meaningful clinical activity in ATC. In the near term, we also look forward to sharing clinical data on ZYBRESTAT in additional cancer indications, such as our study in advanced non-small cell lung cancer (NSCLC) which recently completed enrollment and for which we will present a poster at the EORTC/AACR/NCI meeting in Berlin in November, 2010."

ZYBRESTAT is a vascular disrupting agent (VDA), and one of a novel class of small-molecule drug candidates. Through interaction with vascular endothelial cell cytoskeletal proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and causing death of tumor cells. In clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and selective activity against tumor vasculature, as well as clinical activity against ATC, ovarian cancer and various other solid tumors.

Phase 2/3 Study Results

The FACT Study is a controlled, randomized Phase 2/3 study investigating the addition of ZYBRESTAT (fosbretabulin tromethamine, or CA4P) to chemotherapy (carboplatin and paclitaxel) in patients with anaplastic thyroid cancer (ATC). The FACT study initially anticipated enrollment of 180 patients. Enrollment in the study was truncated and a total of 80 patients were enrolled with 55 in the ZYBRESTAT + chemotherapy arm and 25 in the chemotherapy arm. The treatment arms were well balanced with regard to key patient characteristics except for a greater percentage of females in the control arm. Patients on the study arm received ZYBRESTAT each week and chemotherapy on day 2 of treatment every three weeks. Patients on the control arm received chemotherapy every three weeks. Patients on the study arm could elect to receive CA4P as maintenance therapy after completing 6 cycles of therapy. Maintenance therapy continued until disease progression.

Key Study Results

Median overall survival (OS) was 5.1 months for patients who received ZYBRESTAT and chemotherapy, and 4.1 months for patients who received chemotherapy alone. Hazard ratio (%95 CI): 0.71 (0.42, 1.22).
At one year, 23% of patients whose treatment included ZYBRESTAT were alive compared to 9% of patients treated with chemotherapy alone.
At six months, 48% of patients whose treatment included ZYBRESTAT were alive compared to 37% of patients treated with chemotherapy alone.
In patients less than 60 years of age, median OS was 10.9 months for patients who received ZYBRESTAT and chemotherapy, and 3.1 months for patients who received chemotherapy alone. Hazard ratio (%95 CI): 0.38 (0.16, 0.88).
In patients with stage IVC disease, median OS was 5.0 months for patients who received ZYBRESTAT and chemotherapy, and 3.8 months for patients who received chemotherapy alone. Hazard ratio (%95 CI): 0.63 (0.34, 1.15).
In patients with tumor sizes of greater than 6 cm, median OS was 5.7 months for patients who received ZYBRESTAT and chemotherapy, and 3.9 months for patients who received chemotherapy alone. Hazard ratio (%95 CI): 0.51 (0.22, 1.19).
The improvement in survival in patients with stage IVC disease and with tumor sizes of greater than 6 cm whose treatment included ZYBRESTAT suggests greater antitumor activity of ZYBRESTAT and chemotherapy in more advanced tumors.
ZYBRESTAT in conjunction with chemotherapy was well tolerated, with adverse events primarily related to ATC and disease progression. Myelosuppression was more common in patients receiving ZYBRESTAT and chemotherapy but rates of febrile neutropenia were equally low in both arms. As a result of work done in earlier studies, hypertension management guidelines were implemented and have reduced significant CA4P-induced hypertension and cardiac ischemia.

About ZYBRESTAT (fosbretabulin)

ZYBRESTAT is being evaluated in a Phase 2 study of patients with NSCLC and other clinical trials. OXiGENE believes that ZYBRESTAT is poised to become an important product in a novel class of small-molecule drug candidates called vascular disrupting agents (VDAs). Through interaction with vascular endothelial cell cytoskeletal proteins, ZYBRESTAT selectively targets and collapses tumor vasculature, thereby depriving the tumor of oxygen and nutrients, causing death of tumor cells. In clinical trials in solid tumors, ZYBRESTAT has demonstrated potent and selective activity against tumor vasculature, as well as clinical activity against ATC, ovarian cancer and various other solid tumors.

About OXiGENE

OXiGENE is a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases. The Company's major focus is developing vascular disrupting agents (VDAs) that selectively disrupt abnormal blood vessels associated with solid tumor progression and visual impairment. OXiGENE is dedicated to leveraging its intellectual property and therapeutic development expertise to bring life-extending and life-enhancing medicines to patients.

The OXiGENE, Inc. logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=4969

Safe Harbor Statement

This news release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Any or all of the forward-looking statements in this press release, which include ZYBRESTAT's potential as a new thyroid cancer therapy, discussions with potential partners and OXiGENE's ability to successfully leverage its intellectual property rights and drug development acumen may turn out to be wrong. Forward-looking statements can be affected by inaccurate assumptions OXiGENE might make or by known or unknown risks and uncertainties, including, but not limited to, inability to access working capital, potential negative outcomes of clinical studies of ZYBRESTAT, potential inadequacies in OXiGENE's intellectual property position, and inability to engage potential partners or execute a potential strategic agreement with a partner. Additional information concerning factors that could cause actual results to materially differ from those in the forward-looking statements is contained in OXiGENE's reports to the Securities and Exchange Commission, including OXiGENE's reports on Form 10-K, 10-Q and 8-K. However, OXiGENE undertakes no obligation to publicly update forward-looking statements, whether because of new information, future events or otherwise. Please refer to our Annual Report on Form 10-K for the fiscal year ended December 31, 2009

CONTACT: OXiGENE
Investor and Media Contact:
Michelle Edwards, Investor Relations
650-635-7006 begin_of_the_skype_highlighting 650-635-7006 end_of_the_skype_highlighting
medwards@oxigene.com  

Oxigene Inc. : Approximately 23,608,900 shares changed hands, a 1,947.9 percent increase over its 65-day average volume. The shares rose $.04 or 14.8 percent to $.31.  

So,war das jetzt ein R/S bei sunesis oder sind die gestiegen ?

MFG
Chali  

aber finde es sehr geil wie die abgeht ;-)

ASCO 2011: Opportunities for Biotech Investor Success and Failure

NASDAQ: OXGN Market Cap:$13.2 Million Market Close 04/29/2011at $1.76 PPS

Oxigene will be presenting the final phase 2/3 (FACT study) data for its flagship drug, ZYBRESTAT, for anaplastic thyroid cancer at ASCO. The low PPS and market cap for the company is surprising for a company whose phase III data many are expecting to be positive. Interim data announced in October 2010, were mostly positive with overall survival improvements and good drug tolerance. A good candidate for buyout and for run up to ASCO, this company may see some surprising gains over the next couple of months. A phase 2 trial for ZEBRESTAT for ovarian cancer was initiated in early April, and enrollment has completed in two other ZEBRESTAT trials for advanced platinum-resistant ovarian cancer and non-small cell lung cancer. Please see associated links for information on each trial. Speculation on the upcoming data presentations could provide investors with a volatile run up to ASCO.

http://seekingalpha.com/article/...r-success-and-failure?source=yahoo

Für mich grenzt es schon an ein kleines wunder,dass Oxigene immer noch überlebt hat,ich würde aber bezweifeln wollen,das OXGN Zebrestat bis zur Marktreife bringt,es fehlt einfach das Geld,hm ? Schau dir auch mal Talon Therapeutics an,die laufen noch besser,sind aber schon kurz vor der zulassung ......

MFG
Chali  

umgelegt, stehen wir gerade mal bei 23cent. Der Chart sieht beeindruckender aus, als er ist.  

oxgn hat aus 1-jahres-sicht charttechnisch mehr luft bis ca. 25 usd. bei talon scheint die reise erstmal vorbei... vielleicht  noch ein doppler. danke für den tipp.